Data science concepts and considerations in conducting and interpreting exposome-wide association studies.
Abstract
Central to the exposome concept includes data-driven and comprehensive approaches to identify individuals and mixtures of correlates with disease and health outcomes. Here, we attempt to offer a guide for new researchers on how to interpret and evaluate data-driven exposomic studies. We first introduce the concepts of contributions from genes and environment to phenotypes and data-driven analysis in large observation cohorts. We then give an overview of exposome-wide association studies (ExWAS), a versatile analytical approach to identify robust signals from large and complex exposomic data, and discuss their key considerations and extensions. We also briefly cover emerging topics for exposmic studies, including FAIR Data Principles, administrative healthcare datasets, and functional exposomic data. Finally, for any data-driven study associating multiple exposures with a phenotype and involving correction for multiple comparisons, regardless of data types and research questions, we propose to standardize the terminology for this approach as "exposome-wide association study, ExWAS”. This will facilitate effective communication among researchers and improve literature retrieval.
Author List
Members of the Exposomics Consortium*
The Exposomics Consortium consists of participants in the NIEHS Catalytic Workshop Series on the Exposome. Members were required to opt-in to the roster below.
| Name | Institution | Country |
|---|---|---|
| Jankowska, Marta (Ph.D.) | Beckman Research Institute, City of Hope | United States |
| Peluso, Alina () | DOE | United States |
| Haidari, Ariana () | University of Michigan - Ann Arbor | United States |
| He, Jingxuan () | University of Southern California | United States |
| walker, ryan (Ph.D.) | Mount Sinai School of Medicine | United States |
| Motsinger-Reif, Alison (Ph.D.) | NIEHS | United States |
| Holmes, Philip () | NCIT | United States |
| Adebamowo, Clement (Prof.) | University of Maryland at Baltimore | United States |
| Dolinoy, Dana (Ph.D.) | University of Michigan - Ann Arbor | United States |
| Chatziioannou, Anastasia Chrysovalantou (Ph.D.) | University of Crete | Greece |
| Pan, Shudi () | University of Southern California | United States |
| Teitelbaum, Susan (Ph.D.) | Icahn School of Medicine at Mount Sinai | United States |
| CHUNG, Ming Kei (Ph.D.) | Harvard University | United States |
| Gullapalli, Rama (M.D.,Ph.D.) | University of New Mexico | United States |
| Langston, Mike (Prof.) | University of Tennessee - Knoxville | United States |
| Rushing, Blake (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| Zhang, Xinyue (Ph.D.) | Stanford University | United States |
| Cui, Yuxia (Ph.D.) | NIEHS | United States |
| Dierickx, Erin (Ms.) | University of Connecticut | United States |
| Hart, Jaime (Sc.D.) | Harvard University | United States |
| Lai, Yunjia (Ph.D.) | Columbia University | United States |
| Ruden, Douglas (Ph.D.) | Wayne State University | United States |
| Cheng, Qiwen () | Arizona State University, Tempe Campus | United States |
| KANNAN, srimathik@gmail.com (Ph.D.) | CloudAspirers | United States |
| Konstantinou, Corina (Ms.) | Cyprus University of Technology | Cyprus |
| LaSalle, Janine (Ph.D.) | University of California, Davis | United States |
| Penning, Trevor (Ph.D.) | University of Pennsylvania | United States |
| Parker, Graham (Ph.D.) | Wayne State University / School of Medicine | Canada |
| Breton, Carrie () | University of Southern California | United States |
| Engel, Lawrence (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| Wilson, Ander (Ph.D.) | Colorado State University | United States |
| Scholl, Elizabeth (Ph.D.) | Sciome LLC | United States |
| Gaulke, Christopher (Ph.D.) | University of Illinois at Urbana-Champaign | United States |
| Ji, Hong (Ph.D.) | University of California, Davis | United States |
| Prins, Gail (Ph.D.) | University of Illinois at Chicago | United States |
| Page, Grier (Ph.D.) | RTI International | United States |
| Quintana, Penelope J E (Ph.D.) | San Diego State University | United States |
| Du, Xiuxia (Prof.) | University of North Carolina at Charlotte | United States |
| Paul, Kimberly (Ph.D.) | University of California, Los Angeles | United States |
| Argos, Maria (Ph.D.) | Boston University | United States |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Berger, Kimberly (Ph.D.) | Sequoia Foundation | United States |
| Luo, Jiajun (Ph.D.) | University of Chicago | United States |
| Sturla Irizarry, Savannah (Ms.) | University of Michigan - Ann Arbor | United States |
| Shah, Ruchir (Ph.D.) | Sciome LLC | United States |
| Harari, Homero (Ph.D.) | Mount Sinai School of Medicine | United States |
| Giebelhaus, Ryland T. (Mr.) | University of Alberta | Canada |
| Siwakoti, Ram (Mr.) | University of Michigan - Ann Arbor | United States |
| Bhutani, Jessie () | NIH | United States |
| Sundseth, Scott (Ph.D.) | International HundredK+ Cohorts Consortium | United States |
| Costello, Elizabeth () | University of Southern California | United States |
| Habre, Rima (Sc.D.) | University of Southern California | United States |
| Vijayakumar , Nisha () | University of South Florida | United States |
| Wu, K. Lily (Ph.D.) | California Environmental Protection Agency | United States |
| Soliman, Ghada (Ph.D.) | City University of New York, Graduate School and University Center | United States |
| Cohen Hubal, Elaine () | EPA | United States |
| Bisson, William (Ph.D.) | NIEHS | United States |
| Cooke, Marcus (Ph.D.) | University of South Florida | United States |
| Ouidir, Marion () | INSERM | France |
| Hu, Chiung-Wen (Prof.) | Chung Shan Medical University | Taiwan |
| Baumert, Brittney (Ph.D.) | University of Southern California | United States |
| Goodrich, Jesse (Ph.D.) | University of Southern California | United States |
| Zhu, Yeyi () | Kaiser Permanente Northern California Division of Research | United States |
| States, J Christopher (Ph.D.) | University of Louisville | United States |
| Cai, Lu (M.D.,Ph.D.) | University of Louisville | United States |
| Schüssler-Fiorenza Rose, Sophia Miryam (M.D.,Ph.D.) | Standford University | United States |
| Manz, Katherine () | University of Michigan - Ann Arbor | United States |
| Shahriar, Mohammad (M.D.) | University of Chicago | United States |
| Thessen, Anne (Ph.D.) | University of Colorado at Denver | United States |
| Liang, Donghai (Ph.D.) | Emory University | United States |
| Chao, Mu-Rong (Prof.) | Chung Shan Medical University | Taiwan |
| Tong, Ai Phuong () | University of Washington | United States |
| Zhao, Neil () | University of Michigan - Ann Arbor | United States |
| Ramesh, Aramandla (Ph.D.) | Meharry Medical College | United States |
| Miller, Gary (Ph.D.) | Columbia University | United States |
| Clark, Robert (Ph.D.) | RTI International | United States |
| Liao, Jiawen (Ph.D.) | University of Southern California | United States |
| Adamu, Yau () | University of Iowa | United States |
| Hood, Darryl B. (Ph.D.) | Ohio State University | United States |
| Chung, MIng Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Gao, Peng (Prof.) | University of Pittsburgh | United States |
| wang, yi (M.D.,Ph.D.) | Canadian Nuclear Laboratories | Canada |
| Stingone, Jeanette () | Columbia University | United States |
| PRAJAPATI, NIRMALA (Ms.) | Universite Paris-Saclay/ INSERM | France |
| Hu, Hui (Ph.D.) | Harvard University | United States |
| Leang, Amy () | University of Washington | United States |
| Beglarian, Emily (Ms.) | University of Southern California | United States |
| Conti, David (Ph.D.) | University of Southern California | United States |
| James, Peter (Sc.D.) | Harvard University | United States |
| Grafanaki, Katerina (M.D.,Ph.D.) | University of Patras | Greece |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |
| Whyte, Kathryn (Ph.D.) | Columbia University | United States |
| House, John (M.D.,Ph.D.) | NIEHS | United States |
| Soares, Lissa () | State University of New York at Stony Brook | United States |
| Makris, Konstantinos C. (Prof.) | Cyprus University of Technology | Cyprus |
| Zhang, Qiong () | Henry Ford Health System | United States |
| Yuan, Xin/Jean (Ph.D.) | NIH | United States |
| Rajasekar, Arcot (Raja) (Prof.) | University of North Carolina at Chapel Hill | United States |
| Sun, Yangbo () | University of Tennessee - Memphis | United States |
| Arunachalam, Saravanan (Prof.) | University of North Carolina at Chapel Hill | United States |
| Wu, Lang (Prof.) | University of Hawaii - Manoa | United States |
| Pierce, Brandon () | University of Chicago | United States |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |