Community-level exposomics: A population-centered approach to address public health concerns.
Abstract
Environmental factors affecting health and vulnerability far outweigh genetics in accounting for disparities in health status and longevity in US communities. The concept of the exposome, the totality of exposure from conception onwards, provides a paradigm for researchers to investigate the complex role of the environment on the health of individuals. We propose a complementary framework, community-level exposomics, for population-level exposome assessment. The goal is to bring the exposome paradigm to research and practice on the health of populations, defined by various axes including geographic, social, and occupational. This framework includes the integration of community-level measures of the built, natural and social environments, environmental pollution-derived from conventional and community science approaches, internal markers of exposure that can be measured at the population-level and early responses associated with health status that can be tracked using population-based monitoring. Primary challenges to the implementation of the proposed framework include needed advancements in population-level measurement, lack of existing models with the capability to produce interpretable and actionable evidence and the ethical considerations of labeling geographically-bound populations by exposomic profiles. To address these challenges, we propose a set of recommendations that begin with greater engagement with and empowerment of affected communities and targeted investment in community-based solutions. Applications to urban settings and disaster epidemiology are discussed as examples for implementation.
Author List
Members of the Exposomics Consortium*
The Exposomics Consortium consists of participants in the NIEHS Catalytic Workshop Series on the Exposome. Members were required to opt-in to the roster below.
| Name | Institution | Country |
|---|---|---|
| States, J Christopher (Ph.D.) | University of Louisville | United States |
| Soares, Lissa () | State University of New York at Stony Brook | United States |
| Woo, Jennifer (Ph.D.) | NIEHS | United States |
| Wilson, Ander (Ph.D.) | Colorado State University | United States |
| Costello, Elizabeth () | University of Southern California | United States |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |
| Adebamowo, Clement (Prof.) | University of Maryland at Baltimore | United States |
| Soliman, Ghada (Ph.D.) | City University of New York, Graduate School and University Center | United States |
| Penning, Trevor (Ph.D.) | University of Pennsylvania | United States |
| Zhang, Kai (Ph.D.) | University at Albany | United States |
| Leang, Amy () | University of Washington | United States |
| Chung, MIng Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Peluso, Alina () | DOE | United States |
| Pierce, Brandon () | University of Chicago | United States |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |
| Gaulke, Christopher (Ph.D.) | University of Illinois at Urbana-Champaign | United States |
| Fecho, Karamarie (Ph.D.) | Copperline Professional Solutions, LLC | United States |
| Ruden, Douglas (Ph.D.) | Wayne State University | United States |
| Chao, Mu-Rong (Prof.) | Chung Shan Medical University | Taiwan |
| Luo, Jiajun (Ph.D.) | University of Chicago | United States |
| Liao, Jiawen (Ph.D.) | University of Southern California | United States |
| Engel, Lawrence (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| Liang, Donghai (Ph.D.) | Emory University | United States |
| Zhao, Neil () | University of Michigan - Ann Arbor | United States |
| Lai, Yunjia (Ph.D.) | Columbia University | United States |
| Chatziioannou, Anastasia Chrysovalantou (Ph.D.) | University of Crete | Greece |
| Berger, Kimberly (Ph.D.) | Sequoia Foundation | United States |
| Gullapalli, Rama (M.D.,Ph.D.) | University of New Mexico | United States |
| Shahriar, Mohammad (M.D.) | University of Chicago | United States |
| Cai, Lu (M.D.,Ph.D.) | University of Louisville | United States |
| Clark, Robert (Ph.D.) | RTI International | United States |
| James, Peter (Sc.D.) | Harvard University | United States |
| Rushing, Blake (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| Dierickx, Erin (Ms.) | University of Connecticut | United States |
| Schüssler-Fiorenza Rose, Sophia Miryam (M.D.,Ph.D.) | Standford University | United States |
| Arunachalam, Saravanan (Prof.) | University of North Carolina at Chapel Hill | United States |
| Grafanaki, Katerina (M.D.,Ph.D.) | University of Patras | Greece |
| LaSalle, Janine (Ph.D.) | University of California, Davis | United States |
| Vijayakumar , Nisha () | University of South Florida | United States |
| House, John (M.D.,Ph.D.) | NIEHS | United States |
| Pan, Shudi () | University of Southern California | United States |
| Habre, Rima (Sc.D.) | University of Southern California | United States |
| Bisson, William (Ph.D.) | NIEHS | United States |
| Wu, Lang (Prof.) | University of Hawaii - Manoa | United States |
| Cui, Yuxia (Ph.D.) | NIEHS | United States |
| Dolinoy, Dana (Ph.D.) | University of Michigan - Ann Arbor | United States |
| Du, Xiuxia (Prof.) | University of North Carolina at Charlotte | United States |
| Tong, Ai Phuong () | University of Washington | United States |
| Langston, Mike (Prof.) | University of Tennessee - Knoxville | United States |
| Paul, Kimberly (Ph.D.) | University of California, Los Angeles | United States |
| Ouidir, Marion () | INSERM | France |
| Stanek, Lindsay () | EPA | United States |
| Hart, Jaime (Sc.D.) | Harvard University | United States |
| walker, ryan (Ph.D.) | Mount Sinai School of Medicine | United States |
| Miller, Gary (Ph.D.) | Columbia University | United States |
| Scholl, Elizabeth (Ph.D.) | Sciome LLC | United States |
| Corlin, Laura (Ph.D.) | Tufts University | United States |
| Argos, Maria (Ph.D.) | Boston University | United States |
| Cooke, Marcus (Ph.D.) | University of South Florida | United States |
| Noren Hooten, Nicole (Ph.D.) | NIH | United States |
| Cohen Hubal, Elaine () | EPA | United States |
| CHUNG, Ming Kei (Ph.D.) | Harvard University | United States |
| Baumert, Brittney (Ph.D.) | University of Southern California | United States |
| Goodrich, Jesse (Ph.D.) | University of Southern California | United States |
| Bhutani, Jessie () | NIH | United States |
| Duarte Folle, Aline (Ph.D.) | University of California, Los Angeles | United States |
| Gao, Peng (Prof.) | University of Pittsburgh | United States |
| Page, Grier (Ph.D.) | RTI International | United States |
| Wu, K. Lily (Ph.D.) | California Environmental Protection Agency | United States |
| Konstantinou, Corina (Ms.) | Cyprus University of Technology | Cyprus |
| Zhu, Yeyi () | Kaiser Permanente Northern California Division of Research | United States |
| Motsinger-Reif, Alison (Ph.D.) | NIEHS | United States |
| Zhang, Qiong () | Henry Ford Health System | United States |
| Parker, Graham (Ph.D.) | Wayne State University / School of Medicine | Canada |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Shah, Ruchir (Ph.D.) | Sciome LLC | United States |
| Sun, Yangbo () | University of Tennessee - Memphis | United States |
| Hu, Chiung-Wen (Prof.) | Chung Shan Medical University | Taiwan |
| Cheng, Qiwen () | Arizona State University, Tempe Campus | United States |
| Hanson, Heidi (Ph.D.) | DOE | United States |
| Sturla Irizarry, Savannah (Ms.) | University of Michigan - Ann Arbor | United States |
| Hua, Jenna (Ph.D.) | Million Marker | United States |
| Quintana, Penelope J E (Ph.D.) | San Diego State University | United States |
| Hood, Darryl B. (Ph.D.) | Ohio State University | United States |
| Yuan, Xin/Jean (Ph.D.) | NIH | United States |
| Harari, Homero (Ph.D.) | Mount Sinai School of Medicine | United States |
| Adar, Sara D. (Sc.D.) | University of Michigan - Ann Arbor | United States |
| Dunlop, Anne (M.D.) | Emory University | United States |
| Ji, Hong (Ph.D.) | University of California, Davis | United States |
| Adamu, Yau () | University of Iowa | United States |
| KANNAN, srimathik@gmail.com (Ph.D.) | CloudAspirers | United States |
| Jankowska, Marta (Ph.D.) | Beckman Research Institute, City of Hope | United States |
| Rajasekar, Arcot (Raja) (Prof.) | University of North Carolina at Chapel Hill | United States |
| Beglarian, Emily (Ms.) | University of Southern California | United States |
| Sundseth, Scott (Ph.D.) | International HundredK+ Cohorts Consortium | United States |
| PRAJAPATI, NIRMALA (Ms.) | Universite Paris-Saclay/ INSERM | France |
| Teitelbaum, Susan (Ph.D.) | Icahn School of Medicine at Mount Sinai | United States |
| Ramesh, Aramandla (Ph.D.) | Meharry Medical College | United States |
| Hu, Hui (Ph.D.) | Harvard University | United States |
| Manz, Katherine () | University of Michigan - Ann Arbor | United States |
| Haidari, Ariana () | University of Michigan - Ann Arbor | United States |
| Whyte, Kathryn (Ph.D.) | Columbia University | United States |
| He, Jingxuan () | University of Southern California | United States |
| Makris, Konstantinos C. (Prof.) | Cyprus University of Technology | Cyprus |
| Zhang, Xinyue (Ph.D.) | Stanford University | United States |
| Holmes, Philip () | NCIT | United States |
| wang, yi (M.D.,Ph.D.) | Canadian Nuclear Laboratories | Canada |