Community-level exposomics: A population-centered approach to address public health concerns.
Abstract
Environmental factors affecting health and vulnerability far outweigh genetics in accounting for disparities in health status and longevity in US communities. The concept of the exposome, the totality of exposure from conception onwards, provides a paradigm for researchers to investigate the complex role of the environment on the health of individuals. We propose a complementary framework, community-level exposomics, for population-level exposome assessment. The goal is to bring the exposome paradigm to research and practice on the health of populations, defined by various axes including geographic, social, and occupational. This framework includes the integration of community-level measures of the built, natural and social environments, environmental pollution-derived from conventional and community science approaches, internal markers of exposure that can be measured at the population-level and early responses associated with health status that can be tracked using population-based monitoring. Primary challenges to the implementation of the proposed framework include needed advancements in population-level measurement, lack of existing models with the capability to produce interpretable and actionable evidence and the ethical considerations of labeling geographically-bound populations by exposomic profiles. To address these challenges, we propose a set of recommendations that begin with greater engagement with and empowerment of affected communities and targeted investment in community-based solutions. Applications to urban settings and disaster epidemiology are discussed as examples for implementation.
Author List
Members of the Exposomics Consortium*
The Exposomics Consortium consists of participants in the NIEHS Catalytic Workshop Series on the Exposome. Members were required to opt-in to the roster below.
| Name | Institution | Country |
|---|---|---|
| Jankowska, Marta (Ph.D.) | Beckman Research Institute, City of Hope | United States |
| Peluso, Alina () | DOE | United States |
| Haidari, Ariana () | University of Michigan - Ann Arbor | United States |
| He, Jingxuan () | University of Southern California | United States |
| walker, ryan (Ph.D.) | Mount Sinai School of Medicine | United States |
| Motsinger-Reif, Alison (Ph.D.) | NIEHS | United States |
| Holmes, Philip () | NCIT | United States |
| Adebamowo, Clement (Prof.) | University of Maryland at Baltimore | United States |
| Dolinoy, Dana (Ph.D.) | University of Michigan - Ann Arbor | United States |
| Chatziioannou, Anastasia Chrysovalantou (Ph.D.) | University of Crete | Greece |
| Stanek, Lindsay () | EPA | United States |
| Pan, Shudi () | University of Southern California | United States |
| Teitelbaum, Susan (Ph.D.) | Icahn School of Medicine at Mount Sinai | United States |
| CHUNG, Ming Kei (Ph.D.) | Harvard University | United States |
| Gullapalli, Rama (M.D.,Ph.D.) | University of New Mexico | United States |
| Langston, Mike (Prof.) | University of Tennessee - Knoxville | United States |
| Rushing, Blake (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| Zhang, Xinyue (Ph.D.) | Stanford University | United States |
| Cui, Yuxia (Ph.D.) | NIEHS | United States |
| Dierickx, Erin (Ms.) | University of Connecticut | United States |
| Hart, Jaime (Sc.D.) | Harvard University | United States |
| Lai, Yunjia (Ph.D.) | Columbia University | United States |
| Ruden, Douglas (Ph.D.) | Wayne State University | United States |
| Cheng, Qiwen () | Arizona State University, Tempe Campus | United States |
| KANNAN, srimathik@gmail.com (Ph.D.) | CloudAspirers | United States |
| Konstantinou, Corina (Ms.) | Cyprus University of Technology | Cyprus |
| LaSalle, Janine (Ph.D.) | University of California, Davis | United States |
| Penning, Trevor (Ph.D.) | University of Pennsylvania | United States |
| Parker, Graham (Ph.D.) | Wayne State University / School of Medicine | Canada |
| Noren Hooten, Nicole (Ph.D.) | NIH | United States |
| Dunlop, Anne (M.D.) | Emory University | United States |
| Engel, Lawrence (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| Wilson, Ander (Ph.D.) | Colorado State University | United States |
| Scholl, Elizabeth (Ph.D.) | Sciome LLC | United States |
| Gaulke, Christopher (Ph.D.) | University of Illinois at Urbana-Champaign | United States |
| Ji, Hong (Ph.D.) | University of California, Davis | United States |
| Page, Grier (Ph.D.) | RTI International | United States |
| Quintana, Penelope J E (Ph.D.) | San Diego State University | United States |
| Du, Xiuxia (Prof.) | University of North Carolina at Charlotte | United States |
| Paul, Kimberly (Ph.D.) | University of California, Los Angeles | United States |
| Argos, Maria (Ph.D.) | Boston University | United States |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Berger, Kimberly (Ph.D.) | Sequoia Foundation | United States |
| Luo, Jiajun (Ph.D.) | University of Chicago | United States |
| Sturla Irizarry, Savannah (Ms.) | University of Michigan - Ann Arbor | United States |
| Shah, Ruchir (Ph.D.) | Sciome LLC | United States |
| Harari, Homero (Ph.D.) | Mount Sinai School of Medicine | United States |
| Bhutani, Jessie () | NIH | United States |
| Sundseth, Scott (Ph.D.) | International HundredK+ Cohorts Consortium | United States |
| Costello, Elizabeth () | University of Southern California | United States |
| Habre, Rima (Sc.D.) | University of Southern California | United States |
| Vijayakumar , Nisha () | University of South Florida | United States |
| Wu, K. Lily (Ph.D.) | California Environmental Protection Agency | United States |
| Soliman, Ghada (Ph.D.) | City University of New York, Graduate School and University Center | United States |
| Cohen Hubal, Elaine () | EPA | United States |
| Fecho, Karamarie (Ph.D.) | Copperline Professional Solutions, LLC | United States |
| Hanson, Heidi (Ph.D.) | DOE | United States |
| Bisson, William (Ph.D.) | NIEHS | United States |
| Cooke, Marcus (Ph.D.) | University of South Florida | United States |
| Ouidir, Marion () | INSERM | France |
| Hu, Chiung-Wen (Prof.) | Chung Shan Medical University | Taiwan |
| Hua, Jenna (Ph.D.) | Million Marker | United States |
| Duarte Folle, Aline (Ph.D.) | University of California, Los Angeles | United States |
| Baumert, Brittney (Ph.D.) | University of Southern California | United States |
| Goodrich, Jesse (Ph.D.) | University of Southern California | United States |
| Zhu, Yeyi () | Kaiser Permanente Northern California Division of Research | United States |
| States, J Christopher (Ph.D.) | University of Louisville | United States |
| Cai, Lu (M.D.,Ph.D.) | University of Louisville | United States |
| Schüssler-Fiorenza Rose, Sophia Miryam (M.D.,Ph.D.) | Standford University | United States |
| Manz, Katherine () | University of Michigan - Ann Arbor | United States |
| Shahriar, Mohammad (M.D.) | University of Chicago | United States |
| Zhang, Kai (Ph.D.) | University at Albany | United States |
| Liang, Donghai (Ph.D.) | Emory University | United States |
| Chao, Mu-Rong (Prof.) | Chung Shan Medical University | Taiwan |
| Tong, Ai Phuong () | University of Washington | United States |
| Zhao, Neil () | University of Michigan - Ann Arbor | United States |
| Ramesh, Aramandla (Ph.D.) | Meharry Medical College | United States |
| Miller, Gary (Ph.D.) | Columbia University | United States |
| Clark, Robert (Ph.D.) | RTI International | United States |
| Liao, Jiawen (Ph.D.) | University of Southern California | United States |
| Adar, Sara D. (Sc.D.) | University of Michigan - Ann Arbor | United States |
| Adamu, Yau () | University of Iowa | United States |
| Hood, Darryl B. (Ph.D.) | Ohio State University | United States |
| Chung, MIng Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Gao, Peng (Prof.) | University of Pittsburgh | United States |
| wang, yi (M.D.,Ph.D.) | Canadian Nuclear Laboratories | Canada |
| Corlin, Laura (Ph.D.) | Tufts University | United States |
| PRAJAPATI, NIRMALA (Ms.) | Universite Paris-Saclay/ INSERM | France |
| Hu, Hui (Ph.D.) | Harvard University | United States |
| Leang, Amy () | University of Washington | United States |
| Beglarian, Emily (Ms.) | University of Southern California | United States |
| James, Peter (Sc.D.) | Harvard University | United States |
| Grafanaki, Katerina (M.D.,Ph.D.) | University of Patras | Greece |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |
| Whyte, Kathryn (Ph.D.) | Columbia University | United States |
| House, John (M.D.,Ph.D.) | NIEHS | United States |
| Soares, Lissa () | State University of New York at Stony Brook | United States |
| Makris, Konstantinos C. (Prof.) | Cyprus University of Technology | Cyprus |
| Zhang, Qiong () | Henry Ford Health System | United States |
| Yuan, Xin/Jean (Ph.D.) | NIH | United States |
| Rajasekar, Arcot (Raja) (Prof.) | University of North Carolina at Chapel Hill | United States |
| Sun, Yangbo () | University of Tennessee - Memphis | United States |
| Woo, Jennifer (Ph.D.) | NIEHS | United States |
| Arunachalam, Saravanan (Prof.) | University of North Carolina at Chapel Hill | United States |
| Wu, Lang (Prof.) | University of Hawaii - Manoa | United States |
| Pierce, Brandon () | University of Chicago | United States |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |