A roadmap to advance exposomics through federation of data.
Abstract
The scale of the human exposome, which covers all environmental exposures encountered from conception to death, presents major challenges in managing, sharing, and integrating a myriad of relevant data types and available data sets for the benefit of exposomics research and public health. By addressing these challenges, the exposomics research community will be able to greatly expand on its ability to aggregate study data for new discoveries, construct and update novel exposomics data sets for building artificial intelligence and machine learning-based models, rapidly survey emerging issues, and advance the application of data-driven science. The diversity of the field, which spans multiple subfields of science disciplines and different environmental contexts, necessitates adopting data federation approaches to bridge between numerous geographically and administratively separated data resources that have varying usage, privacy, access, analysis, and discoverability capabilities and constraints. This paper presents use cases, challenges, opportunities, and recommendations for the exposomics community to establish and mature a federated exposomics data ecosystem.
Author List
Members of the Exposomics Consortium*
The Exposomics Consortium consists of participants in the NIEHS Catalytic Workshop Series on the Exposome. Members were required to opt-in to the roster below.
| Name | Institution | Country |
|---|---|---|
| States, J Christopher (Ph.D.) | University of Louisville | United States |
| Soares, Lissa () | State University of New York at Stony Brook | United States |
| Wilson, Ander (Ph.D.) | Colorado State University | United States |
| Costello, Elizabeth () | University of Southern California | United States |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |
| Adebamowo, Clement (Prof.) | University of Maryland at Baltimore | United States |
| Soliman, Ghada (Ph.D.) | City University of New York, Graduate School and University Center | United States |
| Penning, Trevor (Ph.D.) | University of Pennsylvania | United States |
| Chung, MIng Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Peluso, Alina () | DOE | United States |
| Pierce, Brandon () | University of Chicago | United States |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |
| Gaulke, Christopher (Ph.D.) | University of Illinois at Urbana-Champaign | United States |
| Fecho, Karamarie (Ph.D.) | Copperline Professional Solutions, LLC | United States |
| Ruden, Douglas (Ph.D.) | Wayne State University | United States |
| Chao, Mu-Rong (Prof.) | Chung Shan Medical University | Taiwan |
| Luo, Jiajun (Ph.D.) | University of Chicago | United States |
| Liao, Jiawen (Ph.D.) | University of Southern California | United States |
| Liang, Donghai (Ph.D.) | Emory University | United States |
| Zhao, Neil () | University of Michigan - Ann Arbor | United States |
| Lai, Yunjia (Ph.D.) | Columbia University | United States |
| Chatziioannou, Anastasia Chrysovalantou (Ph.D.) | University of Crete | Greece |
| Berger, Kimberly (Ph.D.) | Sequoia Foundation | United States |
| Gullapalli, Rama (M.D.,Ph.D.) | University of New Mexico | United States |
| Shahriar, Mohammad (M.D.) | University of Chicago | United States |
| Cai, Lu (M.D.,Ph.D.) | University of Louisville | United States |
| Clark, Robert (Ph.D.) | RTI International | United States |
| James, Peter (Sc.D.) | Harvard University | United States |
| Rushing, Blake (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| Dierickx, Erin (Ms.) | University of Connecticut | United States |
| Schüssler-Fiorenza Rose, Sophia Miryam (M.D.,Ph.D.) | Standford University | United States |
| Arunachalam, Saravanan (Prof.) | University of North Carolina at Chapel Hill | United States |
| Grafanaki, Katerina (M.D.,Ph.D.) | University of Patras | Greece |
| LaSalle, Janine (Ph.D.) | University of California, Davis | United States |
| Vijayakumar , Nisha () | University of South Florida | United States |
| House, John (M.D.,Ph.D.) | NIEHS | United States |
| Pan, Shudi () | University of Southern California | United States |
| Habre, Rima (Sc.D.) | University of Southern California | United States |
| Wu, Lang (Prof.) | University of Hawaii - Manoa | United States |
| Cui, Yuxia (Ph.D.) | NIEHS | United States |
| Dolinoy, Dana (Ph.D.) | University of Michigan - Ann Arbor | United States |
| Du, Xiuxia (Prof.) | University of North Carolina at Charlotte | United States |
| Tong, Ai Phuong () | University of Washington | United States |
| Langston, Mike (Prof.) | University of Tennessee - Knoxville | United States |
| Paul, Kimberly (Ph.D.) | University of California, Los Angeles | United States |
| Ouidir, Marion () | INSERM | France |
| Stanek, Lindsay () | EPA | United States |
| Hart, Jaime (Sc.D.) | Harvard University | United States |
| walker, ryan (Ph.D.) | Mount Sinai School of Medicine | United States |
| Miller, Gary (Ph.D.) | Columbia University | United States |
| Scholl, Elizabeth (Ph.D.) | Sciome LLC | United States |
| Argos, Maria (Ph.D.) | Boston University | United States |
| Cooke, Marcus (Ph.D.) | University of South Florida | United States |
| Noren Hooten, Nicole (Ph.D.) | NIH | United States |
| Cohen Hubal, Elaine () | EPA | United States |
| CHUNG, Ming Kei (Ph.D.) | Harvard University | United States |
| Goodrich, Jesse (Ph.D.) | University of Southern California | United States |
| Bhutani, Jessie () | NIH | United States |
| Gao, Peng (Prof.) | University of Pittsburgh | United States |
| Page, Grier (Ph.D.) | RTI International | United States |
| Wu, K. Lily (Ph.D.) | California Environmental Protection Agency | United States |
| Konstantinou, Corina (Ms.) | Cyprus University of Technology | Cyprus |
| Motsinger-Reif, Alison (Ph.D.) | NIEHS | United States |
| Zhang, Qiong () | Henry Ford Health System | United States |
| Parker, Graham (Ph.D.) | Wayne State University / School of Medicine | Canada |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Shah, Ruchir (Ph.D.) | Sciome LLC | United States |
| Sun, Yangbo () | University of Tennessee - Memphis | United States |
| Hu, Chiung-Wen (Prof.) | Chung Shan Medical University | Taiwan |
| Cheng, Qiwen () | Arizona State University, Tempe Campus | United States |
| Hanson, Heidi (Ph.D.) | DOE | United States |
| Sturla Irizarry, Savannah (Ms.) | University of Michigan - Ann Arbor | United States |
| Hua, Jenna (Ph.D.) | Million Marker | United States |
| Quintana, Penelope J E (Ph.D.) | San Diego State University | United States |
| Hood, Darryl B. (Ph.D.) | Ohio State University | United States |
| Schmitt, Charles (Ph.D.) | NIEHS | United States |
| Yuan, Xin/Jean (Ph.D.) | NIH | United States |
| Harari, Homero (Ph.D.) | Mount Sinai School of Medicine | United States |
| Adar, Sara D. (Sc.D.) | University of Michigan - Ann Arbor | United States |
| Ji, Hong (Ph.D.) | University of California, Davis | United States |
| Adamu, Yau () | University of Iowa | United States |
| KANNAN, srimathik@gmail.com (Ph.D.) | CloudAspirers | United States |
| Jankowska, Marta (Ph.D.) | Beckman Research Institute, City of Hope | United States |
| Rajasekar, Arcot (Raja) (Prof.) | University of North Carolina at Chapel Hill | United States |
| Giebelhaus, Ryland T. (Mr.) | University of Alberta | Canada |
| Sundseth, Scott (Ph.D.) | International HundredK+ Cohorts Consortium | United States |
| PRAJAPATI, NIRMALA (Ms.) | Universite Paris-Saclay/ INSERM | France |
| Teitelbaum, Susan (Ph.D.) | Icahn School of Medicine at Mount Sinai | United States |
| Ramesh, Aramandla (Ph.D.) | Meharry Medical College | United States |
| Hu, Hui (Ph.D.) | Harvard University | United States |
| Manz, Katherine () | University of Michigan - Ann Arbor | United States |
| Whyte, Kathryn (Ph.D.) | Columbia University | United States |
| He, Jingxuan () | University of Southern California | United States |
| Makris, Konstantinos C. (Prof.) | Cyprus University of Technology | Cyprus |
| Zhang, Xinyue (Ph.D.) | Stanford University | United States |
| Holmes, Philip () | NCIT | United States |
| wang, yi (M.D.,Ph.D.) | Canadian Nuclear Laboratories | Canada |