The Exposome and Nutritional Pharmacology and Toxicology: A New Application for Metabolomics.
Abstract
The exposome refers to all of the internal and external life-long exposures that an individual experiences. These exposures, either acute or chronic, are associated with changes in metabolism that will positively or negatively influence the health and well-being of individuals. Nutrients and other dietary compounds modulate similar biochemical processes and have the potential in some cases to counteract the negative effects of exposures or enhance their beneficial effects. We present herein the concept of Nutritional Pharmacology/Toxicology which uses high-information metabolomics workflows to identify metabolic targets associated with exposures. Using this information, nutritional interventions can be designed toward those targets to mitigate adverse effects or enhance positive effects. We also discuss the potential for this approach in precision nutrition where nutrients/diet can be used to target gene-environment interactions and other subpopulation characteristics. Deriving these “nutrient cocktails” presents an opportunity to modify the effects of exposures for more beneficial outcomes in public health.
Author List
Members of the Exposomics Consortium*
The Exposomics Consortium consists of participants in the NIEHS Catalytic Workshop Series on the Exposome. Members were required to opt-in to the roster below.
| Name | Institution | Country |
|---|---|---|
| States, J Christopher (Ph.D.) | University of Louisville | United States |
| Soares, Lissa () | State University of New York at Stony Brook | United States |
| Costello, Elizabeth () | University of Southern California | United States |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |
| SHARMA, PRADEEP KUMAR (Ph.D.) | CSIR-INDIAN INSTITUTE OF TOXICOLOGY RESEARCH | India |
| Adebamowo, Clement (Prof.) | University of Maryland at Baltimore | United States |
| Soliman, Ghada (Ph.D.) | City University of New York, Graduate School and University Center | United States |
| Penning, Trevor (Ph.D.) | University of Pennsylvania | United States |
| Zhang, Kai (Ph.D.) | University at Albany | United States |
| Chung, MIng Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Peluso, Alina () | DOE | United States |
| Pierce, Brandon () | University of Chicago | United States |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |
| Gaulke, Christopher (Ph.D.) | University of Illinois at Urbana-Champaign | United States |
| Ruden, Douglas (Ph.D.) | Wayne State University | United States |
| Rider, Lisa (M.D.) | NIEHS | United States |
| Chao, Mu-Rong (Prof.) | Chung Shan Medical University | Taiwan |
| Luo, Jiajun (Ph.D.) | University of Chicago | United States |
| Liao, Jiawen (Ph.D.) | University of Southern California | United States |
| Thessen, Anne (Ph.D.) | University of Colorado at Denver | United States |
| Liang, Donghai (Ph.D.) | Emory University | United States |
| Zhao, Neil () | University of Michigan - Ann Arbor | United States |
| Lai, Yunjia (Ph.D.) | Columbia University | United States |
| Chatziioannou, Anastasia Chrysovalantou (Ph.D.) | University of Crete | Greece |
| Berger, Kimberly (Ph.D.) | Sequoia Foundation | United States |
| Gullapalli, Rama (M.D.,Ph.D.) | University of New Mexico | United States |
| Shahriar, Mohammad (M.D.) | University of Chicago | United States |
| Cai, Lu (M.D.,Ph.D.) | University of Louisville | United States |
| Clark, Robert (Ph.D.) | RTI International | United States |
| Rushing, Blake (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| Dierickx, Erin (Ms.) | University of Connecticut | United States |
| Schüssler-Fiorenza Rose, Sophia Miryam (M.D.,Ph.D.) | Standford University | United States |
| Arunachalam, Saravanan (Prof.) | University of North Carolina at Chapel Hill | United States |
| Grafanaki, Katerina (M.D.,Ph.D.) | University of Patras | Greece |
| LaSalle, Janine (Ph.D.) | University of California, Davis | United States |
| House, John (M.D.,Ph.D.) | NIEHS | United States |
| Pan, Shudi () | University of Southern California | United States |
| Habre, Rima (Sc.D.) | University of Southern California | United States |
| Bisson, William (Ph.D.) | NIEHS | United States |
| Stingone, Jeanette () | Columbia University | United States |
| Wu, Lang (Prof.) | University of Hawaii - Manoa | United States |
| Cui, Yuxia (Ph.D.) | NIEHS | United States |
| Dolinoy, Dana (Ph.D.) | University of Michigan - Ann Arbor | United States |
| Du, Xiuxia (Prof.) | University of North Carolina at Charlotte | United States |
| Tong, Ai Phuong () | University of Washington | United States |
| Langston, Mike (Prof.) | University of Tennessee - Knoxville | United States |
| Paul, Kimberly (Ph.D.) | University of California, Los Angeles | United States |
| Ouidir, Marion () | INSERM | France |
| Hart, Jaime (Sc.D.) | Harvard University | United States |
| walker, ryan (Ph.D.) | Mount Sinai School of Medicine | United States |
| Miller, Gary (Ph.D.) | Columbia University | United States |
| Argos, Maria (Ph.D.) | Boston University | United States |
| Cooke, Marcus (Ph.D.) | University of South Florida | United States |
| Cohen Hubal, Elaine () | EPA | United States |
| CHUNG, Ming Kei (Ph.D.) | Harvard University | United States |
| Goodrich, Jesse (Ph.D.) | University of Southern California | United States |
| Bhutani, Jessie () | NIH | United States |
| Gao, Peng (Prof.) | University of Pittsburgh | United States |
| Page, Grier (Ph.D.) | RTI International | United States |
| Wu, K. Lily (Ph.D.) | California Environmental Protection Agency | United States |
| Konstantinou, Corina (Ms.) | Cyprus University of Technology | Cyprus |
| Zhu, Yeyi () | Kaiser Permanente Northern California Division of Research | United States |
| Motsinger-Reif, Alison (Ph.D.) | NIEHS | United States |
| Zhang, Qiong () | Henry Ford Health System | United States |
| Parker, Graham (Ph.D.) | Wayne State University / School of Medicine | Canada |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Shah, Ruchir (Ph.D.) | Sciome LLC | United States |
| Sun, Yangbo () | University of Tennessee - Memphis | United States |
| Hu, Chiung-Wen (Prof.) | Chung Shan Medical University | Taiwan |
| Cheng, Qiwen () | Arizona State University, Tempe Campus | United States |
| Sturla Irizarry, Savannah (Ms.) | University of Michigan - Ann Arbor | United States |
| Quintana, Penelope J E (Ph.D.) | San Diego State University | United States |
| Hood, Darryl B. (Ph.D.) | Ohio State University | United States |
| Yuan, Xin/Jean (Ph.D.) | NIH | United States |
| Harari, Homero (Ph.D.) | Mount Sinai School of Medicine | United States |
| Dunlop, Anne (M.D.) | Emory University | United States |
| Ji, Hong (Ph.D.) | University of California, Davis | United States |
| Adamu, Yau () | University of Iowa | United States |
| KANNAN, srimathik@gmail.com (Ph.D.) | CloudAspirers | United States |
| Jankowska, Marta (Ph.D.) | Beckman Research Institute, City of Hope | United States |
| Rajasekar, Arcot (Raja) (Prof.) | University of North Carolina at Chapel Hill | United States |
| Giebelhaus, Ryland T. (Mr.) | University of Alberta | Canada |
| PRAJAPATI, NIRMALA (Ms.) | Universite Paris-Saclay/ INSERM | France |
| Teitelbaum, Susan (Ph.D.) | Icahn School of Medicine at Mount Sinai | United States |
| Manz, Katherine () | University of Michigan - Ann Arbor | United States |
| Haidari, Ariana () | University of Michigan - Ann Arbor | United States |
| Whyte, Kathryn (Ph.D.) | Columbia University | United States |
| He, Jingxuan () | University of Southern California | United States |
| Makris, Konstantinos C. (Prof.) | Cyprus University of Technology | Cyprus |
| Zhang, Xinyue (Ph.D.) | Stanford University | United States |
| Holmes, Philip () | NCIT | United States |
| wang, yi (M.D.,Ph.D.) | Canadian Nuclear Laboratories | Canada |