The Exposome and Nutritional Pharmacology and Toxicology: A New Application for Metabolomics.
Abstract
The exposome refers to all of the internal and external life-long exposures that an individual experiences. These exposures, either acute or chronic, are associated with changes in metabolism that will positively or negatively influence the health and well-being of individuals. Nutrients and other dietary compounds modulate similar biochemical processes and have the potential in some cases to counteract the negative effects of exposures or enhance their beneficial effects. We present herein the concept of Nutritional Pharmacology/Toxicology which uses high-information metabolomics workflows to identify metabolic targets associated with exposures. Using this information, nutritional interventions can be designed toward those targets to mitigate adverse effects or enhance positive effects. We also discuss the potential for this approach in precision nutrition where nutrients/diet can be used to target gene-environment interactions and other subpopulation characteristics. Deriving these “nutrient cocktails” presents an opportunity to modify the effects of exposures for more beneficial outcomes in public health.
Author List
Members of the Exposomics Consortium*
The Exposomics Consortium consists of participants in the NIEHS Catalytic Workshop Series on the Exposome. Members were required to opt-in to the roster below.
| Name | Institution | Country |
|---|---|---|
| Jankowska, Marta (Ph.D.) | Beckman Research Institute, City of Hope | United States |
| Peluso, Alina () | DOE | United States |
| Haidari, Ariana () | University of Michigan - Ann Arbor | United States |
| He, Jingxuan () | University of Southern California | United States |
| walker, ryan (Ph.D.) | Mount Sinai School of Medicine | United States |
| Motsinger-Reif, Alison (Ph.D.) | NIEHS | United States |
| Holmes, Philip () | NCIT | United States |
| Adebamowo, Clement (Prof.) | University of Maryland at Baltimore | United States |
| Dolinoy, Dana (Ph.D.) | University of Michigan - Ann Arbor | United States |
| Chatziioannou, Anastasia Chrysovalantou (Ph.D.) | University of Crete | Greece |
| Pan, Shudi () | University of Southern California | United States |
| Teitelbaum, Susan (Ph.D.) | Icahn School of Medicine at Mount Sinai | United States |
| CHUNG, Ming Kei (Ph.D.) | Harvard University | United States |
| Gullapalli, Rama (M.D.,Ph.D.) | University of New Mexico | United States |
| Langston, Mike (Prof.) | University of Tennessee - Knoxville | United States |
| Rushing, Blake (Ph.D.) | University of North Carolina at Chapel Hill | United States |
| Zhang, Xinyue (Ph.D.) | Stanford University | United States |
| Cui, Yuxia (Ph.D.) | NIEHS | United States |
| Dierickx, Erin (Ms.) | University of Connecticut | United States |
| Hart, Jaime (Sc.D.) | Harvard University | United States |
| Lai, Yunjia (Ph.D.) | Columbia University | United States |
| Ruden, Douglas (Ph.D.) | Wayne State University | United States |
| Cheng, Qiwen () | Arizona State University, Tempe Campus | United States |
| KANNAN, srimathik@gmail.com (Ph.D.) | CloudAspirers | United States |
| Konstantinou, Corina (Ms.) | Cyprus University of Technology | Cyprus |
| LaSalle, Janine (Ph.D.) | University of California, Davis | United States |
| Penning, Trevor (Ph.D.) | University of Pennsylvania | United States |
| Parker, Graham (Ph.D.) | Wayne State University / School of Medicine | Canada |
| Dunlop, Anne (M.D.) | Emory University | United States |
| Gaulke, Christopher (Ph.D.) | University of Illinois at Urbana-Champaign | United States |
| Ji, Hong (Ph.D.) | University of California, Davis | United States |
| Page, Grier (Ph.D.) | RTI International | United States |
| Quintana, Penelope J E (Ph.D.) | San Diego State University | United States |
| Du, Xiuxia (Prof.) | University of North Carolina at Charlotte | United States |
| Rider, Lisa (M.D.) | NIEHS | United States |
| Paul, Kimberly (Ph.D.) | University of California, Los Angeles | United States |
| Argos, Maria (Ph.D.) | Boston University | United States |
| CHUNG, Ming Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Berger, Kimberly (Ph.D.) | Sequoia Foundation | United States |
| Luo, Jiajun (Ph.D.) | University of Chicago | United States |
| Sturla Irizarry, Savannah (Ms.) | University of Michigan - Ann Arbor | United States |
| Shah, Ruchir (Ph.D.) | Sciome LLC | United States |
| Harari, Homero (Ph.D.) | Mount Sinai School of Medicine | United States |
| Giebelhaus, Ryland T. (Mr.) | University of Alberta | Canada |
| Bhutani, Jessie () | NIH | United States |
| Costello, Elizabeth () | University of Southern California | United States |
| Habre, Rima (Sc.D.) | University of Southern California | United States |
| Wu, K. Lily (Ph.D.) | California Environmental Protection Agency | United States |
| Soliman, Ghada (Ph.D.) | City University of New York, Graduate School and University Center | United States |
| Cohen Hubal, Elaine () | EPA | United States |
| Bisson, William (Ph.D.) | NIEHS | United States |
| Cooke, Marcus (Ph.D.) | University of South Florida | United States |
| Ouidir, Marion () | INSERM | France |
| Hu, Chiung-Wen (Prof.) | Chung Shan Medical University | Taiwan |
| Goodrich, Jesse (Ph.D.) | University of Southern California | United States |
| Zhu, Yeyi () | Kaiser Permanente Northern California Division of Research | United States |
| States, J Christopher (Ph.D.) | University of Louisville | United States |
| Cai, Lu (M.D.,Ph.D.) | University of Louisville | United States |
| Schüssler-Fiorenza Rose, Sophia Miryam (M.D.,Ph.D.) | Standford University | United States |
| Manz, Katherine () | University of Michigan - Ann Arbor | United States |
| Shahriar, Mohammad (M.D.) | University of Chicago | United States |
| Zhang, Kai (Ph.D.) | University at Albany | United States |
| Thessen, Anne (Ph.D.) | University of Colorado at Denver | United States |
| Liang, Donghai (Ph.D.) | Emory University | United States |
| Chao, Mu-Rong (Prof.) | Chung Shan Medical University | Taiwan |
| Tong, Ai Phuong () | University of Washington | United States |
| Zhao, Neil () | University of Michigan - Ann Arbor | United States |
| Miller, Gary (Ph.D.) | Columbia University | United States |
| Clark, Robert (Ph.D.) | RTI International | United States |
| Liao, Jiawen (Ph.D.) | University of Southern California | United States |
| SHARMA, PRADEEP KUMAR (Ph.D.) | CSIR-INDIAN INSTITUTE OF TOXICOLOGY RESEARCH | India |
| Adamu, Yau () | University of Iowa | United States |
| Hood, Darryl B. (Ph.D.) | Ohio State University | United States |
| Chung, MIng Kei (Ph.D.) | Chinese University of Hong Kong | Hong Kong |
| Gao, Peng (Prof.) | University of Pittsburgh | United States |
| wang, yi (M.D.,Ph.D.) | Canadian Nuclear Laboratories | Canada |
| Stingone, Jeanette () | Columbia University | United States |
| PRAJAPATI, NIRMALA (Ms.) | Universite Paris-Saclay/ INSERM | France |
| Grafanaki, Katerina (M.D.,Ph.D.) | University of Patras | Greece |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |
| Whyte, Kathryn (Ph.D.) | Columbia University | United States |
| House, John (M.D.,Ph.D.) | NIEHS | United States |
| Soares, Lissa () | State University of New York at Stony Brook | United States |
| Makris, Konstantinos C. (Prof.) | Cyprus University of Technology | Cyprus |
| Zhang, Qiong () | Henry Ford Health System | United States |
| Yuan, Xin/Jean (Ph.D.) | NIH | United States |
| Rajasekar, Arcot (Raja) (Prof.) | University of North Carolina at Chapel Hill | United States |
| Sun, Yangbo () | University of Tennessee - Memphis | United States |
| Arunachalam, Saravanan (Prof.) | University of North Carolina at Chapel Hill | United States |
| Wu, Lang (Prof.) | University of Hawaii - Manoa | United States |
| Pierce, Brandon () | University of Chicago | United States |
| Akhtari, Farida (Ph.D.) | NIEHS | United States |